Time‑Resolved Biosensing Labels & Kits (Fluorophore Chelated Lanthanide Luminescent Probes with Improved Quantum Efficiency, Tech ID: 08‑093)
Technology Overview: A class of lanthanide‑chelate fluorescent probes that integrate a tailored organic fluorophore (antenna) with a chelated lanthanide ion to achieve enhanced quantum efficiency for ultrasensitive detection of biomolecules. The portfolio also covers synthetic methods, macromolecular conjugates, and assay kits for life‑science detection workflows.
Industry Pain Point: Standard organic dyes suffer from short lifetimes and background autofluorescence, limiting sensitivity in complex samples; robust lanthanide labels require careful antenna design to efficiently harvest light and transfer energy to the metal ion.
NJIT Solution: Engineer antenna‑lanthanide chelates and conjugation chemistries that boost energy transfer and probe brightness, enabling time‑resolved assays with high signal‑to‑background and compatibility with nucleic‑acid and protein detection.
Key Features & Advantages
- Higher quantum efficiency lanthanide probes for sensitive detection.
- Supports kits and conjugates for assay integration.
- Ideal for time‑resolved fluorescence (long lifetimes, large Stokes shifts, sharp emission).
Development Stage: TRL 4–5 – Laboratory validation.
Target Markets
- Life‑science reagents (immunoassays, nucleic‑acid detection)
- Diagnostics & point‑of‑care assay developers
- High‑throughput screening and bioimaging
Commercial & IP Details
- Patent Status: Issued (US9221759B2)
- Patent Link: US9221759B2
Inventors: Maxim Kozlov; Lev Krasnoperov; Salvatore Marras; Arkady Mustaev; Shyamala Pillai; Laura Wirpsza