Superdisintegrant‑Based Composite Particles for Rapid Drug Dispersion and Dissolution (Systems and Methods for Superdisintegrant‑Based Composite Particles for Dispersion and Dissolution of Agents, Tech ID: 12‑045)
Technology Overview: This enables the formation of superdisintegrant‑based composite particles designed to dramatically improve dispersion and dissolution of poorly soluble active agents. Using engineered composite structures, the technology enhances water penetration and rapid particle breakup, overcoming a major bottleneck in oral drug formulation. The system is applicable to a wide range of pharmaceutical compounds and can be integrated into existing continuous or batch manufacturing processes, offering significant formulation flexibility.
Industry Pain Point: Poor aqueous solubility limits bioavailability and formulatability of many small‑molecule drugs.
NJIT Solution: These composite particles deliver rapid disintegration and dispersion, improving dissolution rates without complex reformulation or additional excipients.
Key Features & Advantages
- Rapid dispersion and dissolution of active agents
- Improved bioavailability for poorly soluble drugs
- Compatible with standard pharmaceutical manufacturing
- Scalable particle engineering approach
Development Stage: TRL 5–6 – Validated in laboratory and pilot‑scale studies.
Target Markets
- Oral solid dosage pharmaceuticals
- Generic and specialty drug manufacturers
- Contract development and manufacturing organizations (CDMOs)
Market Opportunity
- Global pharmaceutical excipients market (2026): ~$9B
- CAGR: ~6–7%
- Projected market size (2035): ~$15–17B
Commercial & IP Details
Inventors: Mohammad Azad, Anagha Bhakay, Ecevit Bilgili, Rajesh Dave