Improved Growth Matrices for Stem Cell Propagation


Growth Matrices for Stem Cell Propagation in vitro and in Tissue Regeneration

NJIT Case No. 13-013


Inventors: Cheul Cho, Steven Levison, Nolan Skop, Frances Calderon, Chirag Gandhi


Intellectual Property & Development status: Patent Publication No. US 2015-0361395 A1. US, European, Israel, Canada and China Patent Protection is pending.

NJIT is currently seeking commercial partners for the further development and commercialization of this opportunity.


Technology Brief:

The present invention provides a multifunctional 2-D and 3-D matrix for propagation of stem cells. In particular, a chitosan-based biomaterial scaffold is engineered to promote CNS regeneration from primitive neural precursors by stabilizing a recombinant protein, fibroblast growth factor to preserve the cardinal properties of stem cells. The matrix is further modified by the addition of either the extracellular matrix protein fibronectin or the small peptide RGD or IKVAV. A method to manufacture an injectable multifunctional microsphere scaffold is also disclosed that is suitable as a vehicle for cell transplantation to repair traumatic brain injuries.



Patent Information:
For Information, Contact:
Simon Nynens
VP, Business Incubation
New Jersey Institute of Technology
Steven Levison
Cheul Cho
Nolan Skop
Frances Calderon
Chirag Gandhi
Patent Pending
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