Description:
NJIT Case No. 16-027
QUANTITATIVE OPTICAL COHERENCE ELASTOGRAPHY BASED ON FIBER-OPTIC PROBE FOR IN SITU MEASUREMENT OF TISSUE MECHANICAL PROPERTIES
Inventors: Xuan Liu
Intellectual Property & Development status: US Patent protection is pending.
NJIT is currently seeking commercial partners for the further development and commercialization of this opportunity.
Technology Brief: Researchers at New Jersey Institute of Technology in the Department of Electrical and Computer Engineering have invented a novel Quantitative Optical Coherence Elastography (qOCE) technology for quantitative characterization of tissue’s mechanical properties.
Optical coherence elastography (OCE) is a technique that can be used to mechanical characterization of biological tissue with microscopic resolution. Conventional OCE is based on tissue compression and measures tissue displacement under quasi-static, uniaxial mechanical loading but does not quantify mechanical loading. The invention is a novel quantitative qOCE technology using a unique fiber optic miniature probe with integrated force and displacement sensing functionality for absolute quantitative measurements of tissue mechanical properties such as elasticity. Additionally, this is a smaller system based on miniature fiber optic probe therefore, provides measurement flexibility and can be practiced in arbitrary measurement site that may otherwise be inaccessible.
Applications
• Mechanical Characterization of Material
Industrial and Research use
• Mechanical characterization of tissue properties
Surgical Guidance
Cancer Diagnosis
Tumor margin delineation
Advantages
• Quantitative characterization of mechanical properties
• Flexible and customizable
• Smaller system
Inventors Bio:
Xuan Liu received her B.S. and M.S. degrees from Tsinghua University, and PhD degree from the Johns Hopkins University. She joined the NJIT as a faculty in 2014. Dr. Liu’s expertise lies in optical imaging, fiber optics, and medical instrument based on optical technologies. She has published more than 60 journal and conference papers. Dr. Liu’s current research is supported by New Jersey Institute of Technology and National Institutes of Health.