Description:
System and method for fabrication of uniform polymer films containing nano and micro particles via continuous drying process
NJIT Case No. 13-052
Inventors: Rajesh Dave, Ramani Susarla, Boris Khusid, Anagha A. Bhakay, Ecevit A. Bilgili, Fernando Muzzio
Intellectual Property & Development status: US Patent Protection is pending. Patent Publication No. US 20160022599 A1
NJIT is currently seeking commercial partners for the further development and commercialization of this opportunity.
Technology Brief: Researchers at New Jersey Institute of Technology in the Department of Chemical, Biological and Pharmaceutical Engineering have invented improved systems/methods for fabricating stripfilm based pharmaceutical products. The invention uses higher viscosity film forming precursors and drying methods that accomplish improved/faster drying and provide improved/excellent content uniformity of active pharmaceutical agents in the stripfilm based pharmaceutical products.
Published Patent is available at https://www.google.com/patents/US20160022599
Inventors Bio:
Rajesh Dave is Distinguished professor and the founding Director of the R&D Excellence Center, New Jersey Center for Engineered Particulates in the Otto H. York Department of Chemical, Biological and Pharmaceutical Engineering at NJIT.
He focuses on research and innovations in particle engineering for improved particle properties for applications to pharmaceutical, food, electronics, and energy industries. Under his direction, the center has developed into an important resource for researchers and industry alike in the areas of nanoparticles and nanocomposites. The center is equipped with state-of-the-art equipment for processing and characterizing particles at the nano and submicron levels, and researchers work in partnership with industry to develop tailored particulate materials with unique properties for industry applications. Center research in particle engineering has led to attracting funds from National Science Foundation, National Institute of Health, and other federal agencies as well as industry. These activities have also led to NJIT’s first ever participation in an NSF funded Engineering Research Center on Structured Organic Particulate Systems with a focus on improved materials and manufacturing science for pharmaceutical products. In this NSF-ERC, Prof. Davé is a Site Leader, a Research Thrust Leader and a leader of a particle engineering based technology platform Testbed on drug laden thin films.
His NSF-ERC leadership roles have led to significant impact on pharmaceutical industry through aligning high quality research with the NAE and NIH goals that include better medicines, medications the body can absorb and process efficiently, and designing therapies and dosages that are more precise and flexible. These advancements are expected to have a broad societal impact through improved patient care, patient compliance and comfort and reduced manufacturing costs. Ongoing commercialization activities of transformative technologies are expected to make an impact in a long run at a level of over $B per year.
His research contributions to date include over 150 journal papers, numerous invited and keynote presentations as well as eleven issued and about dozen pending patents. His current research expertise includes engineered particulates with special emphasis on pharmaceuticals products. He has granted 29 PhDs to students at NJIT, six of those students are currently in US academia. He has received numerous awards, most recently, the Board of Overseers Excellence in Research Prize and Medal, NJIT, October 2016 and the Thomas Alva Edison Patent Award Winner, Enabling Technology, November 2016. He has also been engaged in technology development and transfer activities in film coating of very fine particles, bioavailability enhancement, and taste-masking. His work on taste-masking via solventless coating technology has been commercially licensed by a global pharma company.